Andarine is a SARM developed to treat muscle wasting and osteoporosis. It has shown promise in animal research, where it increased bone density and muscle mass. But, it was left in early human clinical trials due to serious safety concerns. People who use it illegally tend to be oblivious of these dangers, which can be downplayed in bodybuilding sites. Read on to learn more about this drug and its side effects.
What Is Andarine? Andarine, also known as S-4, S-40503, or 8, is a SARM developed to treat osteoporosis and muscle wasting. SARMs (Selective Androgen Receptor Modulators) are drugs that bind to the androgen receptor (AR), which is the main site of action of the hormone testosterone. In the first days, S4 sarm (Andarine) was clarified as the perfect SARM due to high oral bioavailability and good muscle- and - bone-building effects (studied in animals). Phase I human trials with this drug have allegedly been successful but no studies have been published. However, further development of the drug was abandoned in favor of Ostarine, another SARM using a similar arrangement, also known as S-22. This was likely because of Andarine's poor safety profile. It caused vision-related side effects, which further increases the long list of reasons from ever taking this drug. Mechanism of Action Andarine has a high affinity for the androgen receptor (AR) and therefore mimics the effects of testosterone. However, its effects are much stronger in bones and muscles than in reproductive organs. That's exactly why Andarine (S4) along with other SARMs are known to cause fewer side effects than anabolic steroids. Bodybuilders often take this unapproved theory as "proof" that they won't have to take care of intense testosterone reduction and increased estrogens should they take SARMs. Nonetheless, this is far from true. The "SARMs selectivity theory" might be absolutely false. It has never been proven, and SARMs such as Andarine and Ostarine never passed appropriate clinical trials. SARMs may turn out to be more dangerous than previously believed. Possible Uses of Andarine This section concentrates on the clinical and scientific research that has been performed on Andarine so far. Anadarine hasn't been properly studied in humans. According to the existing information, its effects are unknown and its potential to cause injury is high. 1) May Increase Muscle Mass This drug was developed to prevent muscle wasting, and animal research does indeed demonstrate that Andarine improves muscle growth and strength in animals. When given to castrated rats for 4 weeks, Andarine increased muscle weight as markedly as DHT (dihydrotestosterone). Moreover, unlike DHT, Andarine caused no prostate enlargement, which is a concern when taking steroids. Twelve weeks after castration, Andarine had been able to restore lean body (muscle) mass in rats. 2) May Increase Bone Power and Combat Osteoporosis Andarine improved bone mineral density and power in both in castrated male rats and in female rats whose ovaries were removed (this is a commonly used animal model of osteoporosis). Andarine may be especially valuable in osteoporosis as a consequence, in addition to enhancing bone density, also, it improves muscle strength, which might reduce the chance of falls and fractures. 3) Fat Loss In female rats whose ovaries have been removed, besides improving bone strength, Andarine also diminished body fat. Side Effects of Andarine Serious Safety Concerns Andarine is an unapproved drug with completely unknown effects on the entire body. SARMs are recognized to have fewer side effects than anabolic steroids. This remains unproven. People misperceive SARMS like Andarine as safer due to a simple misunderstanding of the available scientific data, which can be hyped in various bodybuilding sites. However, the "SARMS selectivity theory," based on which people talk about reduced side effects, has never been proven. SARMs like Andarine never passed appropriate clinical trials. SARMs might even turn out to be more harmful than several other substances (steroids and testosterone contained). LH (luteinizing hormone) and FSH (follicle stimulating hormone) promote the production of reproductive hormones in women and men, and their suppression can suppress normal estrogen/testosterone levels. Andarine suppressed LH and FSH in castrated rats in which these hormones were raised as a result of castration. But, it did not affect normal male rats. All in all, it is unknown if and how much Andarine would suppress testosterone/estrogen generation in people. The most ordinary user-reported side effects are visual issues such as a yellow tint and problem adjusting to night vision. These disappear after the drug was discontinued. Higher doses seem to cause stronger side effects. Some users report depression. Limitations and Caveats The safety and effects of Andarine have not been researched in people or the studies aren't publically available. This drug was mainly tested in rats. Although it is purchased online, its long-term advantages and risks in humans are unknown. Legality, Sports, and Doping
Since 2008, the use of SARMs has been considered doping by the US Anti-Doping Agency (USADA), and such drugs are around the World Anti-Doping Agency (WADA) prohibited list. Using Andarine in aggressive and professional sports is, thus, illegal. This drug isn't approved by the FDA for any purpose.
There's no safe dose for this drug since it has not passed proper clinical trials or received approval from any regulatory body. In rats and dogs, Andarine is bioavailable, with an average half-life of approximately 200 minutes. Here we outlined the available dosage data from online communities with the endeavor to warn people about the dangers of carrying this unapproved drug. According to users, a common dosing range is 50 to 75 mg daily (divided into 3 doses taken with foods). Some start with lower doses of 25 to 50 mg every day. S4 sarm (Andarine) is often cycled. This drug is unapproved, so the quality and the identity of the item is frequently highly questionable. In a study of 44 products marketed as SARMs (such as Andarine), only 52% contained SARMs, and many were inaccurately labeled. We at SARMs Pharm advise talking to some doctor before taking any drug, particularly an unscheduled medication with restricted long-term safety data in humans. Disclaimer: We highly recommend using this medication since its effects and security are unknown. Therefore, we're presenting the available information from the clinical and scientific literature with the intent of helping readers understand the dangers involved.
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